Figure 5 | Scientific Reports

Figure 5

From: Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma

Figure 5

Cannabidiol (CBD) triggered widespread transcriptome changes in head and neck squamous cell carcinoma (HNSCC) cells. (A) FaDu and SCC15 cells were treated with 10 µM CBD and RNA-seq was performed to investigate differentially expressed genes (DEG) by CBD treatment on HNSCCs. The number of up- and down-regulated genes in response to CBD in FaDu and SCC15 cells is indicated, respectively. (B) The Top 50 up- and down-regulated genes in both FaDu and SCC15 were represented by color images and value of fold change (twofold difference with p < 0.05). Color depicted the levels of fold change. (C) The representative up-regulated genes encoding DUSP1 and KLF6 in CBD-treated FaDu and SCC15 cells were confirmed by quantitative real-time RT-PCR. Data indicated mean and SD; *p < 0.05; **p < 0.01; and ***p < 0.001 compared with the corresponding control.

Back to article page