Figure 6
From: Novel multimodal molecular imaging of Vitamin H (Biotin) transporter activity in the murine placenta
Resolving biotin mediated aggregates assembly and dispersion kinetics based on a three-compartment model. (a) T1-weighted 3D-GRE image of a representative placenta. Voxel-by-voxel analysis was performed on all placentae producing six parametric maps: (b) k12 map of the contrast material unidirectional exchange rate from the maternal vasculature (C1) to the placental intravascular compartment (C2). (c) k23 map of the exchange rate between C2 to trophoblast cells compartment (C3). (d–f) \(T_{2}^{*}\) maps of the placenta during the three kinetic phases: elevation, reduction, and recovery. \(T_{2}^{*}\) values changed in tandem with the formation and clearance of contrast agent aggregation pattern (see Eq. 6). (g) V23 map, representing the percentage of C2 and C3 compartments in a chosen slice. (h) Histogram of V23 values for the placenta.
