Figure 7

(a) Comparative biodistribution of [¹⁸F]Biotin (structure shown) of fetuses and placentae under non-blocking and blocking conditions. Biodistribution data was obtained ~ 1 h post injection/post PET. (b) A summed coronal slice view (55–60 min) of an entire mouse under non-blocking conditions. White arrows are pointing to visible placentae. L = liver, G = gut, B = bladder. (c) A summed coronal slice view (55–60 min) of an entire mouse under blocking conditions. White arrows are pointing to visible placentae. (d) Average standard uptake values over time in the fetuses of the same non-blocking mouse (b, n = 15) and blocking mouse (c, n = 10). (e) Average standard uptake values over time in the placentae of the same mice. Standard uptake values were calculated from the regions of interests drawn around the fetuses and placentae.