Figure 1 | Scientific Reports

Figure 1

From: 18F-meta-fluorobenzylguanidine (18F-mFBG) to monitor changes in norepinephrine transporter expression in response to therapeutic intervention in neuroblastoma models

Figure 1

(a) Simplified radiosynthesis scheme of 18F-mFBG by copper-mediated deborylation. (b) Total NET-1 protein expression in selected NB cell lines determined by Western blot. Full length blots are presented in Supplementary Figure WB1. (c) 18F-mFBG (top bar chart) and 123I-mIBG (bottom bar chart) radiotracer uptake in NB cell lines for 1 h at 37 °C, inhibited with and without 50 µM desipramine (DMI; 15 min pre-incubation). Data are presented as mean ± SEM, n ≥ 2 per group, performed in triplicate. Graphs are generated using GraphPad Prism (v 8.4.1), https://www.graphpad.com.

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