Figure 5 | Scientific Reports

Figure 5

From: Targeting macrophage priming by polyphyllin VII triggers anti-tumor immunity via STING-governed cytotoxic T-cell infiltration in lung cancer

Figure 5

PP VII boosts macrophage activity relying on STING. (a–c) RAW 264.7s and THP-1s were pretreated with C-176 and H-151 respectively then primed with IFN-γ in absence or presence of PP VII (a,b). RAW 264.7s with DMXAA pretreatment were primed with IFN-γ following inhibitor incubation (c). RT-qPCR analysis of triplicates from two independent experiments is shown as mean + SD. ***p < 0.001, **p < 0.01, *p < 0.05, ns no significant.

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