Table 2 Efficacy of synthesized arylhydrazothiazole derivative 5a applied at its respective MFC alone or conjugated with anti-dermatophyte monoclonal antibody 0014 in treatment of skin infection of guinea pigs due to inoculation with a dermatophyte, 45 days post inoculation as compared with fluconazole as standard fungicide applied at MFC respective dose for each fungus.
Treatment | Percent healing | |||||
|---|---|---|---|---|---|---|
Compound 5a | Fluconazole | |||||
E. floccosum | M. canis | T. rubrum | E. floccosum | M. canis | T. rubrum | |
Inoculated, untreated | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
Inoculated, treated with thiazole compound | 77.6 ± 3.9 | 90.5 ± 6.4 | 84.6 ± 4 | 72.0 ± 6.2 | 86.0 ± 5.0 | 84.8 ± 3.8 |
Inoculated, treated with thiazole compound conjugated with antigen | 98.1 ± 4.4 | 100 | 100 | 82.3 ± 4.6 | 95.0 ± 4.4 | 92.3 ± 5.3 |
