Figure 4 | Scientific Reports

Figure 4

From: Hormonal and biochemical changes in female Proechimys guyannensis, an animal model of resistance to pilocarpine-induced status epilepticus

Figure 4

Changes in hippocampal progesterone and oestrogen receptor expression in NOVX and OVX animals following pilocarpine treatment. Progesterone receptor expression increased along the status epilepticus (SE) timeline (30 min for NOVX and 90 min for OVX). Within 90 min of SE onset, the expression of oestrogen receptor (ER)-alpha decreased and that of ER-beta increased markedly in NOVX animals. As such, ER-alpha expression was higher than ER-beta expression in both OVX and NOVX animals. (a) Progesterone receptor expression. (b) ER-alpha expression. (c) ER-beta expression. (d) Comparative optical densities (OD) between ER-alpha and ER-beta. CTR: Control; NOVX: Non-ovariectomised animals; OVX: Ovariectomised animals. β-Actin was used for normalisation. All hippocampal samples were run through the gel simultaneously (uncropped gels are presented in Supplementary Information B as Figures S4–S6). Data are presented as mean ± SD. Levels marked with asterisk (*) indicate significant differences: *p < 0.05, **p < 0.01, ***p < 0.001.

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