Table 2 Colocalization of oestrogen and progesterone receptors with GABA_B and mGluR2/3 receptors in the hippocampi of females Proechimys guyannensis.

From: Hormonal and biochemical changes in female Proechimys guyannensis, an animal model of resistance to pilocarpine-induced status epilepticus

Groups	GABA_B				mGluR2/3
Groups	CA1	CA3	DG	Hilus	CA1	CA3	DG	Hilus
ER-alpha
CTR-NOVX	0.77 ± 0.005	0.81 ± 0.01	0.72 ± 0.01	0.73 ± 0.005	0.34 ± 0.01	0.54 ± 0.01	0.46 ± 0.03	0.64 ± 0.006
CTR-OVX	0.87 ± 0.005	0.76 ± 0.03	0.80 ± 0.006	0.60 ± 0.006	0.59 ± 0.006	0.55 ± 0.01	0.68 ± 0.01	0.58 ± 0.01
PILO 30-NOVX	0.78 ± 0.01	0.78 ± 0.01	0.46 ± 0.02**	0.47 ± 0.005**	0.58 ± 0.06	0.60 ± 0.006	0.55 ± 0.07	0.64 ± 0.006
PILO 30-OVX	0.75 ± 0.004	0.81 ± 0.006	0.72 ± 0.01	0.73 ± 0.01	0.63 ± 0.01	0.53 ± 0.06	0.53 ± 0.05**	0.48 ± 0.08
PILO 90-NOVX	0.76 ± 0.01	0.82 ± 0.03	0.68 ± 0.01	0.72 ± 0.005	0.66 ± 0.01**	0.65 ± 0.006**	0.71 ± 0.006**	0.60 ± 0.006
PILO 90-OVX	0.71 ± 0.03*	0.74 ± 0.01	0.66 ± 0.01**	0.78 ± 0.03**	0.54 ± 0.01^##	0.50 ± 0.006	0.62 ± 0.006	0.48 ± 0.02
ER-beta
CTR-NOVX	0.05 ± 0.005	0.18 ± 0.01	0.05 ± 0.006	0.04 ± 0.006	0.23 ± 0.08	0.22 ± 0.01	0.35 ± 0.06	0.22 ± 0.01
CTR-OVX	0.40 ± 0.002	0.43 ± 0.01	0.46 ± 0.006	0.43 ± 0.006	0.21 ± 0.01	0.39 ± 0.05	0.36 ± 0.03	0.23 ± 0.01
PILO 30-NOVX	0.27 ± 0.01**	0.35 ± 0.006**	0.19 ± 0.01	0.28 ± 0.05*	0.07 ± 0.01*	0.21 ± 0.01	0.24 ± 0.02	0.24 ± 0.01
PILO 30-OVX	0.20 ± 0.006*	0.21 ± 0.006*	0.38 ± 0.01	0.26 ± 0.03	0.19 ± 0.01	0.26 ± 0.02**	0.24 ± 0.02	0.24 ± 0.01
PILO 90-NOVX	0.17 ± 0.02	0.29 ± 0.03	0.29 ± 0.01**	0.25 ± 0.06	0.15 ± 0.01	0.29 ± 0.01^#	0.24 ± 0.01	0.23 ± 0.01
PILO 90-OVX	0.21 ± 0.01*	0.25 ± 0.006	0.26 ± 0.01**	0.19 ± 0.01**	0.19 ± 0.01	0.33 ± 0.01	0.24 ± 0.00	0.20 ± 0.01
Progesterone
CTR-NOVX	0.37 ± 0.006	0.51 ± 0.07	0.35 ± 0.01	0.40 ± 0.01	0.20 ± 0.003	0.38 ± 0.02	0.44 ± 0.01	0.24 ± 0.01
CTR-OVX	0.46 ± 0.01	0.55 ± 0.02	0.57 ± 0.04	0.90 ± 0.006	0.36 ± 0.1	0.54 ± 0.005	0.50 ± 0.07	0.58 ± 0.01
PILO 30-NOVX	0.37 ± 0.006	0.52 ± 0.01	0.05 ± 0.006**	0.48 ± 0.09	0.29 ± 0.01	0.63 ± 0.09	0.36 ± 0.006	0.67 ± 0.01*
PILO 30-OVX	0.42 ± 0.01	0.46 ± 0.01	0.09 ± 0.005	0.81 ± 0.01**	0.75 ± 0.02	0.48 ± 0.03	0.76 ± 0.01	0.57 ± 0.006
PILO 90-NOVX	0.27 ± 0.02	0.43 ± 0.005	0.06 ± 0.006	0.46 ± 0.005	0.35 ± 0.01**	0.34 ± 0.01^##	0.40 ± 0.02	0.73 ± 0.006**
PILO 90-OVX	0.40 ± 0.02	0.42 ± 0.01**	0.08 ± 0.005*	0.89 ± 0.006	0.24 ± 0.01^##	0.39 ± 0.02**	0.30 ± 0.03^#	0.44 ± 0.01*

ER-alpha: Oestrogen receptor alpha; ER-beta: Oestrogen receptor beta; GABA_B: Gamma-aminobutyric acid; mGluR2/3: Metabotropic glutamate receptor; CTR-NOVX: Non-ovariectomised control group, animals no submitted to SE; CTR-OVX: Ovariectomised control group, animals no submitted to SE; PILO 30-NOVX, Non-ovariectomised animals analysed 30 min after SE onset; PILO 30-OVX: Ovariectomised animals analysed 30 min after SE onset; PILO 90-NOVX, Non-ovariectomised animals analysed 90 min after SE onset; PILO 90-OVX: Ovariectomised animals analysed 90 min after SE onset. Data are presented as mean ± SD. Kruskal–Wallis test followed by Dunn’s post hoc test. *p < 0.05, **p < 0.01 versus CTR-NOVX or CTR-OVX. ^#p < 0.05, ^##p < 0.01 versus PILO 30-NOVX or PILO 30-OVX.

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Table 2 Colocalization of oestrogen and progesterone receptors with GABA_B and mGluR2/3 receptors in the hippocampi of females Proechimys guyannensis.

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