Figure 3
From: Depletion of circulating IgM memory B cells predicts unfavourable outcome in COVID-19
Normal spleen architecture (male, 58 years old, splenectomised during pancreatic surgery). (A) usual representation of the white and red pulp (HE, ×20); immunohistochemistry with antibodies anti-CD79a (B) and anti-CD3 (C) demonstrates normal distribution of B and T cell areas around vessels (SABC, 20x, Dako Omnis automatic platform). Spleen parenchyma in minimally invasive autopsies of COVID-19 infected patients: D–F) male, 69 years old; G–I) female, 71 years old; D, G) white pulp appears diminished (HE, ×10) due to reduction of both B CD79a+ (E, H) and T CD3+ areas (F, I) (E, F, H, I: SABC 20x, Dako Omnis automatic platform).
