Figure 3
Accuracy and repeatability. (A) Region-of-interest (ROIdataset1) was defined by significant clusters in dataset 1 (c.f. Figure 2A). Receiver operating characteristic (ROC) curves and area-under-curve (AUC) for differential diagnosis was based on mean rSDBOLD values in datasets 2 (B) and 3 (C) within this ROIdataset1. Confidence intervals and statistical significance are also shown. (D) Within-individual changes in the average rSDBOLD in ROIdataset1 over time after baseline imaging (0 months) in AD patients and controls in dataset 1. There was statistical difference between the two groups at both 6 and 12 months. Data represents the mean ± standard error of the mean. Mixed-effect analysis significance between groups p < 0.035 and between timepoints p < 0.0054 corrected for multiple comparison. Predicted mean increase was in AD 21% and in controls 5%. (E) presents indexed rSDBOLD change and Clinical Dementia Rating (CDR) global values in follow up in patients.
