Figure 4 | Scientific Reports

Figure 4

From: The variability of functional MRI brain signal increases in Alzheimer's disease at cardiorespiratory frequencies

Figure 4

source mapping. (A) MREGBOLD signal is imaged with fast sampling rate (TR = 0.1 s). A representative 60 s clip is shown for the purposes of illustration. MREGBOLD signal is bandpass filtered to physiological frequencies to study the cardiac, respiratory and VLF parts of the signal. (B) Differences in rSDBOLD and SD of bandpass filtered signals according to whole-brain voxel-wise analyses. Maps represent group-level differences where SD is higher in Alzheimer’s disease patients (P < 0.05, family wise error corrected). (C) Blood pressure (BP) while supine just prior to entering the MR scanner. (D) Heart and respiration rates from peripheral pulse oximeter and respiration belt, respectively. (E) Heart and respiration rates determined on MREG signal and their correlation to peripheral signals. NS = not significant.

Physiological

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