Table 2 Survival at 5 years of diagnosis, according to treatment received and type of polymorphism.
Variable | Chemotherapy (179 patients and 136 events) | Other treatments (112 patients and 69 events) | ||||||
|---|---|---|---|---|---|---|---|---|
Crude HR (95% CI) | p-value | Adjusted HRa (95% CI) | p-value | Crude HR (95% CI) | p-value | Adjusted HRa (95% CI) | p-value | |
GSTM1 | ||||||||
Salvage gene/heterozygous | 1 (–) | 1 (–) | 1 (–) | 1 (–) | ||||
Homozygous | 1.12 (0.71–1.76) | 0.63 | 1.22 (0.77–1.94) | 0.39 | 0.56 (0.29–1-07) | 0.08 | 0.83 (0.36–1.88) | 0.65 |
GSTT1 | ||||||||
Salvage gene/heterozygous | 1 (–) | 1 (–) | 1 (–) | 1 (–) | ||||
Homozygous | 1.34 (0.81–2.21) | 0.26 | 1.35 (0.81–2.26) | 0.25 | 0.9 (0.41–1.98) | 0.79 | 1.17 (0.48–2.84) | 0.72 |
XRCC1 rs25487 | ||||||||
GG | 1 (–) | 1 (–) | 1 (–) | 1 (–) | ||||
AG | 1.2 (0.81–1.79) | 0.36 | 1.2 (0.8–1.79) | 0.37 | 1.09 (0.63–1.87) | 0.84 | 1.54 (0.84–2.82) | 0.21 |
AA | 1.21 (0.7–2.1) | 0.48 | 1.58 (0.89–2.79) | 0.12 | 0.82 (0.29–2.32) | 0.66 | 1.12 (0.32–3.86) | 0.91 |
ERCC1 rs11615 | ||||||||
CC | 1 (–) | 1 (–) | 1 (–) | 1 (–) | ||||
CT | 0.89 (0.54–1.46) | 0.64 | 1.06 (0.64–1.74) | 0.83 | 0.58 (0.29–1.19) | 0.14 | 0.76 (0.35–1.65) | 0.52 |
TT | 0.62 (0.36–1.06) | < 0.001 | 0.8 (0.46–1.4) | 0.44 | 0.7 (0.34–1.45) | 0.41 | 0.97 (0.45–2.09) | 0.94 |
ERCC1 rs3212986 | ||||||||
GG | 1 (–) | 1 (–) | 1 (–) | 1 (–) | ||||
GT | 1.29 (0.88–1.89) | 0.19 | 1.08 (0.73–1.61) | 0.69 | 1.19 (0.68–2.07) | 0.63 | 1.02 (0.57–1.82) | 0.95 |
TT | 1.75 (0.89–3.45) | 0.11 | 1.64 (0.83–3.25) | 0.16 | 3.65 (1.56–8.51) | < 0.001 | 3.28 (1.33–8.11) | 0.01 |
ERCC2 rs13181 | ||||||||
TT | 1 (–) | 1 (–) | 1 (–) | 1 (–) | ||||
GT | 0.83 (0.56–1.23) | 0.36 | 0.93 (0.62–1.38) | 0.71 | 0.75 (0.42–1.32) | 0.39 | 1.05 (0.56–1.96) | 0.74 |
GG | 1.22 (0.68–2.19) | 0.51 | 1.12 (0.62–2.03) | 0.71 | 1.56 (0.74–3.33) | 0.25 | 1.94 (0.86–4.4) | 0.11 |
XRCC3 rs861539 | ||||||||
CC | 1 (–) | 1 (–) | 1 (–) | 1 (–) | ||||
TC | 0.9 (0.6–1.35) | 0.61 | 1 (0.67–1.5) | 0.99 | 0.84 (0.49–1.45) | 0.62 | 1 (0.56–1.79) | 0.91 |
TT | 0.65 (0.36–1.16) | 0.15 | 0.88 (0.49–1.58) | 0.66 | 0.93 (0.38–2.27) | 0.87 | 0.99 (0.4–2.44) | 0.96 |
OGG1 rs1052133 | ||||||||
CC | 1 (–) | 1 (–) | 1 (–) | 1 (–) | ||||
CG | 1.05 (0.71–1.55) | 0.81 | 1 (0.68–1.48) | 0.99 | 0.83 (0.47–1.47) | 0.47 | 0.56 (0.3–1.03) | 0.05 |
GG | 2.28 (1.04–4.97) | 0.04 | 1.63 (0.73–3.62) | 0.23 | 3.49 (1.05–11.54) | 0.05 | 1.32 (0.39–4.42) | 0.70 |
AAT | ||||||||
MM | 1 (–) | 1 (–) | 1 (–) | 1 (–) | ||||
MS | 1.19 (0.78–1.8) | 0.42 | 1.03 (0.66–1.6) | 0.91 | 1.42 (0.77–2.61) | 0.30 | 0.93 (0.48–1.8) | 0.73 |
MZ | 0.65 (0.09–4.7) | 0.67 | 0.98 (0.13–7.34) | 0.98 | 1.36 (0.33–5.62) | 0.70 | 1.19 (0.27–5.33) | 0.82 |
SZ | 5.65 (0.76–41.81) | 0.09 | 3.3 (0.43–25.09) | 0.25 | 2 (0.27–14.69) | 0.51 | 2 (0.24–16.49) | 0.50 |
SS | 0.37 (0.05–2.69) | 0.33 | 0.45 (0.06–3.29) | 0.43 | 0.77 (0.11–5.58) | 0.78 | 3.52 (0.42–29.55) | 0.25 |
