Table 3 Survival at 5 years, according to the different polymorphisms and treatment received for patients in Stage IV.
Variable | Chemotherapy (119 patients and 106 events) | Other treatments (58 patients and 49 events) | ||||||
|---|---|---|---|---|---|---|---|---|
Crude HR (95% CI) | p-value | Adjusted HRa (95% CI) | p-value | Crude HR (95% CI) | p-value | Adjusted HRa (95% CI) | p-value | |
GSTM1 | ||||||||
Salvage gene/heterozygous | 1 (–) | 1 (–) | 1 (–) | 1 (–) | ||||
Homozygous | 1.34 (0.8–2.24) | 0.26 | 1.4 (0.83–2.33) | 0.20 | 1.01 (0.45–2.28) | 0.97 | 1.11 (0.43–2.87) | 0.82 |
GSTT1 | ||||||||
Salvage gene/heterozygous | 1 (–) | 1 (–) | 1 (–) | 1 (–) | ||||
Homozygous | 1.31 (0.73–2.33) | 0.36 | 1.32 (0.74–2.35) | 0.35 | 1.16 (0.48–2.8) | 0.75 | 1.45 (0.53–3.95) | 0.46 |
XRCC1 rs25487 | ||||||||
GG | 1 (–) | 1 (–) | 1 (–) | 1 (–) | ||||
AG | 1.19 (0.76–1.86) | 0.44 | 1.18 (0.76–1.84) | 0.46 | 1.22 (0.63–2.37) | 0.56 | 1.46 (0.69–3.09) | 0.32 |
AA | 1.84 (0.96–3.55) | 0.07 | 1.73 (0.88–3.37) | 0.11 | 3.19 (1.06–9.64) | 0.04 | 2.28 (0.61–8.57) | 0.22 |
ERCC1 rs11615 | ||||||||
CC | 1 (–) | 1 (–) | 1 (–) | 1 (–) | ||||
CT | 0.97 (0.57–1.66) | 0.92 | 1 (0.59–1.7) | 0.99 | 0.74 (0.32–1.72) | 0.49 | 0.66 (0.27–1.63) | 0.37 |
TT | 0.73 (0.4–1.34) | 0.31 | 0.75 (0.41–1.38) | 0.36 | 1.11 (0.49–2.51) | 0.80 | 1.1 (0.47–2.53) | 0.83 |
ERCC1 rs3212986 | ||||||||
GG | 1 (–) | 1 (–) | 1 (–) | 1 (–) | ||||
GT | 1.19 (0.77–1.82) | 0.43 | 1.14 (0.73–1.76) | 0.57 | 1.11 (0.56–2.17) | 0.77 | 0.94 (0.47–1.86) | 0.85 |
TT | 1.56 (0.69–3.52) | 0.28 | 1.53 (0.68–3.45) | 0.30 | 1.87 (0.62–5.59) | 0.26 | 2.86 (0.9–9.12) | 0.08 |
ERCC2 rs13181 | ||||||||
TT | 1 (–) | 1 (–) | 1 (–) | 1 (–) | ||||
GT | 0.85 (0.54–1.34) | 0.49 | 0.85 (0.54–1.33) | 0.47 | 0.78 (0.39–1.58) | 0.49 | 1.01 (0.49–2.08) | 0.97 |
GG | 1.06 (0.56–2.01) | 0.85 | 1.05 (0.55–1.98) | 0.89 | 1.08 (0.45–2.58) | 0.86 | 1.62 (0.64–4.06) | 0.30 |
XRCC3 rs861539 | ||||||||
CC | 1 (–) | 1 (–) | 1 (–) | 1 (–) | ||||
TC | 0.97 (0.63–1.51) | 0.90 | 0.98 (0.63–1.52) | 0.93 | 1.11 (0.58–2.13) | 0.75 | 1.2 (0.62–2.33) | 0.59 |
TT | 0.77 (0.37–1.6) | 0.48 | 0.78 (0.37–1.64) | 0.51 | 0.97 (0.28–3.34) | 0.96 | 0.76 (0.22–2.69) | 0.67 |
OGG1 rs1052133 | ||||||||
CC | 1 (–) | 1 (–) | 1 (–) | 1 (–) | ||||
CG | 1.09 (0.7–1.68) | 0.71 | 1.07 (0.69–1.66) | 0.75 | 0.77 (0.38–1.57) | 0.47 | 0.56 (0.27–1.17) | 0.12 |
GG | 1.83 (0.78–4.28) | 0.16 | 1.66 (0.69–3.97) | 0.25 | 1.73 (0.52–5.83) | 0.37 | 1.28 (0.38–4.34) | 0.69 |
AAT | ||||||||
MM | 1 (–) | 1 (–) | 1 (–) | 1 (–) | ||||
MS | 1.12 (0.7–1.79) | 0.6507 | 1.07 (0.65–1.76) | 0.7832 | 1.36 (0.64–2.89) | 0.4172 | 1 (0.46–2.18) | 0.99 |
MZ | 7.75 (1.01–59.67) | 0.0494 | 6.89 (0.86–55.45) | 0.0695 | 0.51 (0.07–3.79) | 0.5112 | 0.83 (0.1–6.6) | 0.87 |
SZ | 4.64 (0.62–34.7) | 0.1351 | 4.15 (0.53–32.31) | 0.174 | 0.93 (0.13–6.86) | 0.9407 | 1.28 (0.16–10.39) | 0.82 |
SS | 0.57 (0.08–4.16) | 0.583 | 0.61 (0.08–4.49) | 0.628 | – | – | ||
