Figure 10 | Scientific Reports

Figure 10

From: Sonodynamic therapy in combination with photodynamic therapy shows enhanced long-term cure of brain tumor

Figure 10

Representative histopathological staining of various organs (100 μm thickness) of BALB/c mice (A) without injecting the PAA cationic NPs to mice (control) and at day 14 post-injection of the NPs at a dose of (B) 2 mg/200 μλ/mouse and (C) 20 mg/200 μλ/mouse (tenfold higher dose of the NPs requires to inject (i. v.) a desired therapeutic dose (0.47 μmole/kg) of HPPH. No organ toxicity was observed even at tenfold higher dose of the NPs used for injecting a therapeutic dose (0.47 μmole/kg) of HPPH. The weights of mice used in this study were in the range of 20–24 g/mouse.

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