Figure 2
From: Positioning of an unprecedented spiro[5.5]undeca ring system into kinase inhibitor space
Classification of kinase inhibitors11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27. (A) Typical ATP competitive inhibitors, (B) the binding mode of ATP competitive inhibitors, (C) example kinase inhibitors of each class, and (D) the binding mode of non-ATP competitive inhibitors. The left of (D) is p38 complex with GW434756X (type IV inhibitor in the C-terminal domain). The right of (D) shows the MEK complex with PD318088 (a type III inhibitor between the p-loop and activation loop). The gate keeper (green), hinge (green), DFG residues of the A-loop (violet), P-loop (red), helix (yellow), and C-terminal domain (blue) are shown.
