Table 3 IC50 Measurement of the GSK3β activity of 1,5-oxaza spiroquinone compound 2j in several ATP concentrations.

From: Positioning of an unprecedented spiro[5.5]undeca ring system into kinase inhibitor space

Compound

ATP concentration (µM)

1

10

50

100

200

2ja

2.65

3.53

3.79

4.04

3.45

Staurosporineb

5.05

6.49

19.44

32.24

140.20

  1. aCompound 2j was tested in the 10-dose IC50 mode with a threefold serial dilution starting at 10 μM, and the unit of IC50 is µM.
  2. bStaurosporine was tested in the 10-dose IC50 mode with fourfold serial dilution starting at 20 μM, and the unit of IC50 is nM.
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