Table 1 The used sets of patients for MS disease progression, their selection criteria, patients’ characteristics, number of visits per patients in the first 5 years, and ratio of patients with no year visits for the first 5 years.

SP development

187

SP developed 21 patients (11%)

i) Tracked since onset diagnosis or with SP diagnosis only after the 5\({\mathrm{th}}\) year of tracking;

Gender: 51 men (27%);

1st year: 1.57±0.93;

1st year: 0.00;

ii) Minimum of 5 years of tracking;

Onset age: 31.10±10.54;

2nd year: 1.25±1.27;

2nd year: 0.36;

iii) Minimum of 5 annotated visits;

Tracked years: 11.01±8.18;

3rd year: 1.14±1.06;

3rd year: 0.35;

Annotated years 13.22±4.87;

4\({\mathrm{th}}\) year: 1.19±1.03;

4\({\mathrm{th}}\) year:0.32;

5\({\mathrm{th}}\) year: 1.28±0.91;

5\({\mathrm{th}}\) year: 0.22;

Disease severity in the 6th year

145

Severe cases 38 patients (26%)

i) Tracked since onset diagnosis

Gender: 44 men (28%);

1st year: 1.61±0.96;

1st year: 0.00;

ii) Minimum of 6 years of tracking;

Onset Age: 30.28±10.89;

2nd year: 1.28±1.20;

2nd year: 0.33;

iii) Minimum of 5 annotated visits;

Tracked years: 10.67±7.89;

3rd year: 1.14±1.06;

3rd year: 0.32;

Annotated years 13.82±4.76;

4\({\mathrm{th}}\) year: 1.23±1.05;

4\({\mathrm{th}}\) year: 0.30;

5\({\mathrm{th}}\) year: 1.37±0.92;

5\({\mathrm{th}}\) year: 0.19;

Disease severity in the 10th year

67

Severe cases 30 patients (45%)

i) Tracked since onset diagnosis

Gender: 15 men (27%);

1st year: 1.19±0.47;

1st year: 0.00;

ii) Minimum of 10 years of tracking;

Onset age: 32.30±11.84;

2nd year: 0.52±0.88;

2nd year: 0.64;

iii) Minimum of 5 annotated visits;

Tracked years: 15.24±10.35;

3rd year: 0.61±0.74;

3rd year: 0.54;

Annotated years 15.90±4.83;

4\({\mathrm{th}}\) year: 0.75±0.94;

4\(^{\mathrm{th}}\) year: 0.51;

5\({\mathrm{th}}\) year: 0.87±0.80;

5\(^{\mathrm{th}}\) year: 0.36;