Figure 1
From: Targeting continuity of care and polypharmacy to reduce drug–drug interaction
Policy-relevant proportions using different mediators. This figure demonstrated three policy-relevant proportions of the effect of COC on the DDI events: the proportion eliminated (INTref + INTmed + PIE/TE), the proportion mediated (INTmed + PIE/TE) and the proportion of interaction (INTref + INTmed/TE). With different mediators, the constitute of the effect of COC on DDI events differs. The proportion mediated was higher in the model with excessive polypharmacy (≥ 10 medications concurrently used) than the one with polypharmacy (≥ 5 medications concurrently used); while the proportion of interaction was greater treating polypharmacy as mediator instead. The proportion eliminated declined during the study period using excessive polypharmacy as a mediator.
