Table 2 Four-way decomposition of the relationship between COC, polypharmacy, and DDI.

	2011		2012		2013		2014		2015		2016		2017
	β^a,b	p	β	p	β	p	β	p	β	p	β	p	β	p
Mediator at 0
Total excess RR	− 0.565	< 0.001	− 0.576	< 0.001	− 0.581	< 0.001	− 0.602	< 0.001	− 0.619	< 0.001	− 0.612	< 0.001	− 0.622	< 0.001
Excess RR due to controlled direct effect	0.004	0.193	0.004	0.131	0.008	0.003	0.001	0.878	0.007	0.020	0.003	0.251	0.005	0.112
Excess RR due to reference interaction	− 0.533	< 0.001	− 0.546	< 0.001	− 0.551	< 0.001	− 0.564	< 0.001	− 0.589	< 0.001	− 0.578	< 0.001	− 0.589	< 0.001
Excess RR due to mediated interaction	0.043	< 0.001	0.043	< 0.001	0.048	< 0.001	0.052	< 0.001	0.055	< 0.001	0.053	< 0.001	0.057	< 0.001
Excess RR due to pure indirect effect	− 0.079	< 0.001	− 0.078	< 0.001	− 0.086	< 0.001	− 0.090	< 0.001	− 0.092	< 0.001	− 0.091	< 0.001	− 0.096	< 0.001
Mediator at 1
Total excess RR	− 0.565	< 0.001	− 0.576	< 0.001	− 0.581	< 0.001	− 0.602	< 0.001	− 0.619	< 0.001	− 0.612	< 0.001	− 0.622	< 0.001
Excess RR due to controlled direct effect	− 0.568	< 0.001	− 0.579	< 0.001	− 0.583	< 0.001	− 0.602	< 0.001	− 0.621	< 0.001	− 0.612	< 0.001	− 0.620	< 0.001
Excess RR due to reference interaction	0.039	< 0.001	0.038	< 0.001	0.040	< 0.001	0.039	< 0.001	0.039	< 0.001	0.036	< 0.001	0.036	< 0.001
Excess RR due to mediated interaction	0.043	< 0.001	0.043	< 0.001	0.048	< 0.001	0.052	< 0.001	0.055	< 0.001	0.053	< 0.001	0.057	< 0.001
Excess RR due to pure indirect effect	− 0.079	< 0.001	− 0.078	< 0.001	− 0.086	< 0.001	− 0.090	< 0.001	− 0.092	< 0.001	− 0.091	< 0.001	− 0.096	< 0.001

Quick links

Search