Table 2 Tissue/serum concentration ratio for PZ-DHA in Balb/c female mice.

From: Metabolism and pharmacokinetics of a novel polyphenol fatty acid ester phloridzin docosahexaenoate in Balb/c female mice

Time (min)

Tissue/serum ratio of PZ-DHA (Mean ± SD)

Liver/serum

Lungs/serum

Kidneys/serum

Spleen/serum

Brain/serum

15

0.14 ± 0.06

3.33 ± 1.51

0.66 ± 0.03

3.29 ± 1.56

0.51 ± 0.17

30

0.16 ± 0.08

2.04 ± 1.09

1.29 ± 0.22

3.17 ± 0.72

0.64 ± 0.11

60

4.68 ± 2.02*

1.05 ± 0.014

0.81 ± 0.34

4.18 ± 1.01

0.95 ± 0.68

90

2.69 ± 2.17*

3.51 ± 2.44

0.89 ± 0.26

5.24 ± 1.75

1.01 ± 0.19

120

1.03 ± 0.73

3.82 ± 1.74

2.71 ± 1.41*

10.86 ± 8.42

1.31 ± 0.67

240

0.99 ± 0.23

4.97 ± 1.37

2.71 ± 1.08*

16.15 ± 5.98*

1.94 ± 0.75*

  1. Tissue/serum concentration ratios for PZ-DHA were compared at each time point, considering 15 min as the baseline (n = 4). *p < 0.05. (Liver/serum p = 0.0004; Kidneys/serum p = 0.002; Spleen/serum p = 0.003; Brain/serum p = 0.01).
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