Figure 14 | Scientific Reports

Figure 14

From: DNA damage in lens epithelial cells exposed to occupationally-relevant X-ray doses and role in cataract formation

Figure 14

Proposed model of DNA damage-induced cataract. In the upper panel, the normal process of differentiation from LEC to lens fiber cells (LFC) comprises loss of the nuclear envelope (in black) and consequent degradation of the nucleus (in light blue color). In the lower panel, X-ray-induced DNA damage causes an increase of p21, which impedes the disassembly of the nuclear envelope, thus impairing differentiation and leading to cataract formation.

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