Figure 1 | Scientific Reports

Figure 1

From: Muscle and epidermal contributions of the structural protein β-spectrin promote hypergravity-induced motor neuron axon defects in C. elegans

Figure 1

A mutant of the UNC-70 β-spectrin gene suppresses hypergravity-induced axon defects in DD/VD motor neurons. Wild-type (N2) and mutant C. elegans strains bearing a GFP marker for DD/VD motor neurons of C. elegans (juIs76 strain) were exposed to either normal 1G gravity (A–D) or 100G hypergravity (E–H) during embryonic and larval development. Yellow arrows indicate axon defects. Scale bar indicates 100 μm. (I) Quantification of axon defects in various mutant strains in 1G (grey) or 100G (black) gravity. N = total number of animals analyzed. Statistical significance between 1 and 100G determined by student’s T-test. *p < 0.05, **indicates p < 0.01, *** p < 0.001, NS indicates no significance. Error bars indicate standard error. (J) Increase or decrease in the percent axon defects between 1 and 100G hypergravity. Statistical significance between N2 and each mutant strain determined by student’s T-test. * p < 0.05, **p < 0.01, ***p < 0.001, NS indicates no significance. Error bars indicate standard error.

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