Table 2 Summary of the studies included in this meta-analysis.

From: Postoperative nutritional outcomes and quality of life-related complications of proximal versus total gastrectomy for upper-third early gastric cancer: a meta-analysis

Study (publish year)

Study Design

Period of surgery

Country

Patients criteria

Approach (N)

Surgery type

Anastomosis type

Age (years)

Male (%)

BMI (kg/m2)

1. PG with DTR

Ko et al. (2019)32

C

2008–2016

Korea

cT1, cT2

PG (52)

O/L

DTR

61.5 ± 12.5

67.3

23.7 ± 3.1

TG (52)

O/L

RY

63.0 ± 9.2

67.3

23.4 ± 2.9

Nomura et al. (2019)22

R

2012–2016

Japan

cStage I

PG (15)

L

DTR

65.7 ± 10.6

89.7

n.s

PG (15)

L

JI

69.3 ± 6.0

73.3

n.s

TG (30)

L

RY

68.5 ± 8.3

70

n.s

Cho et al. (2018)33

R

2014–2015

Korea

pStage I

PG (38)

L/R

DTR

55.8 ± 11.6

84.2

24.2 ± 3.1

TG (42)

L/R

RY

59.3 ± 11.8

73.8

23.5 ± 3.0

Furukawa et al. (2018)21

R

2010–2016

Japan

cStage I

PG (27)

L

DTR/EG

70 (59–84)†

81.5

22.8 (19.3–26.8)†

TG (48)

L

RY

63.5 (29–82)†

72.9

22.2 (13.9–26.5)†

Park et al. (2018)34

R

2011–2015

Korea

cStage I

PG (34)

L

DTR

64.1 ± 12.2

76.5

23.1 ± 3.2

TG (46)

L

RY

56.7 ± 11.8

47.8

22.9 ± 3.4

Sugiyama et al. (2018)35

R

2013–2016

Japan

cStage IA

PG (10)

L

DTR

65.6 ± 3.8

70

21.3 ± 1.0

TG (20)

L

RY

68.6 ± 2.7

85

23.7 ± 0.7

Jung et al. (2017)36

R

2003–2015

Korea

pStage I

PG (92)

L

DTR

59.8 ± 11.4

83.7

23.5 ± 2.7

TG (156)

L

RY

58.7 ± 10.8

76.9

23.9 ± 3.3

Kim and Kim (2016)37

C

2009–2014

Korea

cStage IA

PG (17)

L

DTR

64.7 ± 9.9

82.4

24.2 ± 3.8

TG (17)

L

RY

60.9 ± 12.9

58.8

23.4 ± 5.0

2. PG with non-DTR

Asaoka et al. (2019)38

R

2010–2014

Japan

cStage I

PG (39)

O

EG/ JI

66 (38–86)†

84.6

23.2 ± 3.10

TG (73)

O

RY

70 (46–860)†

78.1

23.4 +  ± 3.20

Zhou et al. (2019)39

R

1980–2012

China

pT1, pT2

PG (67)

n.s

EG/DTR/JI

n.s

n.s

n.s

TG (47)

n.s

RY

n.s

n.s

n.s

Ushimaru et al. (2018)40

C

2004–2013

Japan

cStage I

PG (39)

O

EG

67 (44–83)†

82.1

23.0 (18.3–28.0)†

TG (39)

O

RY

69 (34–83)†

79.5

22.7 (16.6–30.9)†

Nishigori et al. (2017)41

R

2006–2014

Japan

cStage I

PG (20)

L

EG

66.2 ± 13.4

75

23.4 ± 3.8

TG (42)

L

RY

64.4 ± 12.2

67

22.8 ± 3.6

Hosoda et al. (2016)42

C

2009–2014

Japan

cT1

PG (16)

L

EG

69.2 ± 8.2

75

22.9 ± 2.6

TG (16)

L

RY

67.7 ± 8.4

69

23.6 ± 3.7

Huh et al. (2015)43

R

2002–2012

Korea

cT1

PG (192)

O/L

EG

59.7 ± 11.2

67.7

24.3 ± 2.9

TG (157)

O

RY

57.4 ± 11.9

73.0

23.5 ± 3.1

Kosuga et al. (2015)16

R

2009–2014

Japan

cStage I

PG (25)

L

EG

66 (41–80)†

68

22.3 (17.7–28.0)†

TG (52)

L

RY

67 (40–89)†

86.5

23.6 (19.0–42.8)†

Ohashi et al. (2015)44

R

2007–2012

Japan

cT1

PG (65)

O

JI

67 (37–77)†

85

23.7 ± 2.9

TG (117)

O

RY

67 (30–84)†

71

23.5 ± 3.4

Isobe et al. (2014)23

R

1989–2008

Japan

pT1

PG (66)

n.s

EG

71.6 ± 9.6

78.8

n.s

PG (23)

n.s

JI

59.4 ± 8.5

78.3

n.s

PG (12)

n.s

JPI

59.9 ± 9.8

75

n.s

TG (38)

n.s

n.s

61.3 ± 9.5

78.9

n.s

Masuzawa et al. (2014)45

R

1998–2005

Japan

pT1

PG (49)

O/L

EG

64.0 ± 7.7

73.5

n.s

PG (32)

O/L

JI

65.0 ± 12.1

78.1

n.s

TG (122)

O/L

RY

63.0 ± 10.0

73.0

n.s

Son et al. (2014)46

R

2001–2008

Korea

cT1

PG (64)

O

EG

58.0 ± 13.3

67.2

n.s

TG (106)

O

RY

61.3 ± 10.3

71.7

n.s

Ahn et al. (2013)47

R

2003–2009

Korea

cStage I

PG (50)

L

EG

58.8 ± 12.1

72

24.2 ± 3.7

TG (81)

L

RY

59.7 ± 11.8

69.1

23.6 ± 3.4

Nozaki et al. (2013)48

R

1999–2008

Japan

cStage I

PG (102)

O

JI

67 (44–85)†

77

n.s

TG (49)

O

RY

71 (34–86)†

73

n.s

Namikawa et al. (2012)49

R

2004–2010

Japan

cStage I

PG (22)

O

JPI

63 (49–77)†

72.7

n.s

TG (22)

O

RY

65 (38–87)†

77.3

n.s

An et al. (2008)50

R

2000–2005

Korea

pT1

PG (89)

n.s

EG

56.6 ± 10.9

69.7

n.s

TG (334)

n.s

RY

55.1 ± 12.1

68.3

n.s

Kitano et al. (2007)51

R

1994–2003

Japan

pT1

PG (54)

L

EG

63.7 ± 9

75.9

§

TG (55)

L

RY

62.1 ± 12

81.8

§

Kondoh et al. (2007)52

R

1997–2004

Japan

pStage IA

PG (10)

O

EG

67.8 ± 5.9

90

23.6 ± 1.8

TG (10)

O

RY

61.4 ± 8.5

90

24.1 ± 2.7

  1. *Values presented as mean ± standard deviation unless indicated otherwise.
  2. †Values with parenthesis presented as median (range).
  3. §Data presented as range are shown in Supplementary Table S1 online.
  4. BMI, body mass index; C, case–control; R, retrospective cohort; PG, proximal gastrectomy; TG, total gastrectomy; L, laparoscopic; O, open; R, robotic; DTR, double-tract reconstruction; EG, esophagogastrostomy; JI, jejunal interposition; JPI, jejunal pouch interposition; RY, Roux-en Y; n.s., not stated.
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