Table 3 Adverse effects reported by the patients with CYP3A4 normal/high and low expression.

From: Association of clozapine-related metabolic disturbances with CYP3A4 expression in patients with schizophrenia

Adverse event

Normal/high CYP3A4 expression (n = 51) [%]

Low CYP3A4 expression (n = 14) [%]

P valuea

Thinking and concentration

66.7

71.4

0.76

Hypersalivation

64.7

71.4

0.52

Blurred vision

33.3

42.9

0.48

Constipation

47.1

71.4

0.06

Fatigue and dizziness

74.5

50.0

0.11

  1. aP values are from a logistic regression model with CYP3A4 expression as predictor variable and occurrence of patient reported adverse effects as predicted variable.
  2. P value indicating marginally significant effect is in bold.
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