Table 7 SEM estimates of the associations between LBP, inflammation, obesity, dyslipidemia, insulin resistance and pre-HTN/HTN.
From: Biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia
Non standardized estimates | Standardized estimates | ||
|---|---|---|---|
Estimate (95% CI) | Estimate (95% CI) | p value | |
Loadings of the biomarkers CRP, TNF-α and IL-6 for the latent variable inflammation | |||
CRP | 1.000 | 0.871 (0.761, 0.981) | < 0.001 |
TNF-α | 0.012 (− 0.087, 0.110) | 0.012 (− 0.086, 0.109) | 0.82 |
IL-6 | 0.060 (0.031, 0.089) | 0.345 (0.219, 0.472) | < 0.001 |
Regression of inflammation on LBP | |||
LBP | 0.304 (0.245, 0.363) | 0.714 (0.604, 0.823) | < 0.001 |
Regression of obesity on inflammation, sex, age at interview, CRT | |||
Inflammation | 0.097 (0.041, 0.153) | 0.324 (0.216, .552) | < 0.001 |
Sex (M vs. F) | − 0.248 (− 0.607, 0.111) | − 0.117 (− 0.278, 0.049) | 0.17 |
Age at interview | 0.009 (− 0.019, 0.038) | 0.056 (− 0.113, 0.223) | 0.52 |
CRT (yes vs. no) | 0.185 (− 0.198, 0.567) | 0.086 (− 0.088, 0.256) | 0.34 |
Regression of dyslipidemia on inflammation, sex, age at interview, CRT | |||
Inflammation | 0.082 (0.024, 0.139) | 0.274 (0.099, 0.448) | < 0.01 |
Sex (M vs. F) | 0.197 (− 0.168, 0.561) | 0.093 (− 0.079, 0.266) | 0.29 |
Age at interview | 0.031 (0.001, 0.062) | 0.188 (0.011, 0.365) | 0.04 |
CRT (yes vs. no) | 0.125 (− 0.247, 0.498) | 0.058 (− 0.115, 0.231) | 0.51 |
Regression of insulin resistance on inflammation, sex, age at interview, CRT | |||
Inflammation | 0.115 (0.056, 0.173) | 0.381 (0.212, 0.549) | < 0.001 |
Sex (M vs. F) | − 0.127 (− 0.544, 0.290) | − 0.060 (− 0.255, 0.135) | 0.55 |
Age at interview | 0.006 (− 0.032, 0.044) | 0.037 (− 0.187, 0.261) | 0.75 |
CRT (yes vs. no) | 0.253 (− 0.180, 0.686) | 0.117 (− 0.079, 0.313) | 0.24 |
Regression of pre-HTN/HTN on inflammation adjusted for sex, age at interview, CRT | |||
Inflammation | 0.014 (− 0.085, 0.113) | 0.046 (− 0.276, 0.367) | 0.78 |
Sex (M vs. F) | 0.801 (0.239, 1.363) | 0.371 (0.142, 0.600) | < 0.01 |
Age at interview | − 0.007 (− 0.050, 0.035) | − 0.043 (− 0.291, 0.205) | 0.73 |
CRT (yes vs. no) | 0.234 (− 0.270, 0.737) | 0.106 (− 0.121, 0.333) | 0.36 |
Goodness of fit measures: CFI = 0.997, TLI = 0.997, RMSEA (90% CI) = 0.010 (0.000, 0.056), SRMR = 0.090 | |||
