Figure 6 | Scientific Reports

Figure 6

From: Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome

Figure 6

Deficiency in ApoE or LDLR results in limited changes in platelet proteome. Highly purified platelets from wild-type, Apoe−/− and Ldlr−/− mice were used for quantitative proteome analysis after shot-gun proteolysis. Ratios of 1,533 unique proteins were quantified by label-free proteomics analysis. (A) Median peptide ratios per protein were log2 transformed and plotted as a function of − log10 P values. Depicted are volcano plots comparing platelets from (A) Apoe−/− with corresponding wild-type mice, and (B) Ldlr−/− with wild-type mice. Dotted line indicates P = 0.05 (t test). (C) Venn diagram of number of proteins with a > 1.5-fold down- (green) or upregulation (red) in platelets from Apoe−/− and Ldlr−/− mice, as compared to wild-types.

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