Table 1 Demographic data of participants.

From: Cognitive impairment is associated with mitochondrial dysfunction in peripheral blood mononuclear cells of elderly population

Variables

Normal (n = 428)

MCI (n = 469)

p-value

Age (years)

72 (4)

74 (4)

< 0.001

Sex (Male)

139 (32.5%)

120 (25.5%)

0.022

Systolic blood pressure (mmHg)

145 (18)

148 (19)

0.003

Diastolic blood pressure (mmHg)

75 (10)

74 (10)

0.725

Body mass index (kg/m2)

24.28 (3.47)

24.33 (4.01)

0.860

Waist to hip ratio

0.93 (0.07)

0.94 (0.06)

0.001

MoCA score

27.83 (1.33)

21.60 (3.12)

< 0.001

ADL score

19.85 (0.48)

19.67 (0.95)

< 0.001

IADL score

7.97 (0.16)

7.83 (0.16)

< 0.001

Education

Primary school (n, %)

13 (3.0%)

60 (12.8%)

< 0.001

High school (n, %)

27 (6.3%)

84 (17.9%)

Vocational (n, %)

109 (25.5%)

154 (32.8%)

Bachelor (n, %)

225 (52.6%)

152 (32.3%)

Master and above (n, %)

54 (12.6%)

20 (4.3%)

Underlying diseases

Diabetes mellitus (n, %)

89 (20.9%)

115 (25.1%)

0.151

Hypertension (n, %)

234 (55.1%)

283 (61.8%)

0.047

Dyslipidemia (n, %)

258 (60.8%)

268 (58.6%)

0.536

Blood parameters

White blood cell (cell/mm3)

6211 (1581)

6379 (1680)

0.123

Hemoglobin (g/dL)

13.75 (1.40)

13.65 (1.32)

0.254

Percent Neutrophil (%)

57 (9)

58 (9)

0.368

Percent lymphocyte (%)

32 (8)

32 (8)

0.261

Triglyceride (mg/dL)

117 (52)

118 (60)

0.703

HDL-C (mg/dL)

61 (16)

58 (17)

0.043

LDL-C (mg/dL)

127 (39)

120 (35)

0.005

VLDL-C (mg/dL)

23 (10)

24 (12)

0.683

AST (U/L)

25 (9)

25 (16)

0.929

ALT (U/L)

23 (12)

23 (26)

0.788

ALP (U/L)

68 (21)

69 (24)

0.652

Glucose (mg/dL)

100 (22)

104 (27)

0.019

Albumin (g/dL)

4.70 (0.29)

4.65 (0.30)

0.004

Globulin (g/dL)

2.76 (0.45)

2.86 (0.43)

0.001

Albumin/Globulin ratio

1.76 (0.38)

1.67 (0.32)

< 0.001

eGFR (mL/min/1.73m2)

62.58 (20.48)

57.05 (19.87)

< 0.001

  1. Continuous variables are presented as mean (standard deviation) and are compared between normal and MCI participants by Student’s t-test. Categorical variable is presented as number with percent and are compared by the chi-square test. Bold values represent a statistical significance.
  2. ADL activities of daily living, ALP alkaline phosphatase, ALT alanine aminotransferase, AST aspartate aminotransferase, eGFR estimated glomerular filtration rate, HDL-C High-density lipoprotein cholesterol, IADL instrumental activities of daily living, LDL-C Low-density lipoprotein cholesterol, MoCA Montreal cognitive assessment, VLDL-C Very low-density lipoprotein cholesterol.
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