Table 3 Correlation analysis of mutation rates and centrality indices shows that there is no statistically significant correlation between any of the centrality indices and normalized mutation rates. Mutation data are from a study by Kunstman et al.37.

From: Network analysis reveals essential proteins that regulate sodium-iodide symporter expression in anaplastic thyroid carcinoma

 

Betweenness

Closeness

Clustering coefficient

Degree

DMNC

EPC

MNC

Correlation

 − 0.0782

 − 0.0784

0.1077

 − 0.0827

0.1483

 − 0.0689

 − 0.0827

P value

0.3138

0.3122

0.1647

0.2868

0.0551

0.3746

0.2864

 

Radiality

Stress

Total average

Group 1 average †

Group 2 average

Group 3 average

Weighted average

Correlation

 − 0.0828

 − 0.0769

 − 0.0369

0.1512

 − 0.0765

0.0262

 − 0.0644

P value

0.2858

0.3217

0.6345

0.0504

0.3241

0.7361

0.4069

  1. †Group and weighted averages have been defined as following:
  2. Group 1 average: average of ranks of DMNC and CC.
  3. Group 2 average: average of ranks of closeness, radiality, betweenness, stress and EPC.
  4. Group 3 average: average of ‘Group 1 average', ‘Group 2 average’ and ranks of degree.
  5. Weighted average: average of ‘Group 1 average × 0.1’, ‘Group 2 average ✕ 0.7’ and ranks of ‘degree × 0.2’.
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