Figure 6
From: Cell non-autonomous requirement of p75 in the development of geniculate oral sensory neurons
Neural deletion of p75 results in a moderate loss of fungiform taste buds. The tongues from 9–12-month-old Phox2b-Cre; p75fx/fx and Phox2b-WT; p75fx/fx mice were serially sectioned, H&E stained and the number of taste buds within fungiform papillae counted. While the majority of fungiform papillae contained taste buds with normal morphology (A), some had abnormal, shrunken taste buds or none at all (B). (C) Quantification of the number of taste buds revealed a reduction in Phox2b-Cre; p75fx/fx mice compared to Phox2b-WT; p75fx/fx mice. (D) Numbers of fungiform papillae were unchanged between genotypes. (E) The number of taste buds in 2–3-month-old Phox2b-Cre; p75fx/fx mice was reduced as compared to Phox2b-WT; p75fx/fx mice. Sample sizes are 3–6 mice per group and data are graphed as the mean ± SEM. * is p < 0.05. Scale bar in (B) is 25 μm.
