Table 3 Drug-gene interactions of TMPRSS2-correlated genes.
From: Gene expression network analysis provides potential targets against SARS-CoV-2
Gene | No. of drug-gene interactions‡ | r (TMPRSS2) | p | FDR |
|---|---|---|---|---|
CDKL2 | 1 | 0.61 | 1.77 × 10–116 | 1.11 × 10–114 |
ITGB6 | 4 | 0.61 | 9.72 × 10–113 | 5.66 × 10–111 |
SCN1A | 75 | 0.57 | 4.39 × 10–95 | 1.25 × 10–93 |
LRRK2 | 25 | 0.56 | 2.22 × 10–93 | 5.92 × 10–92 |
LAMA3 | 2 | 0.55 | 4.64 × 10–89 | 1.11 × 10–87 |
HMGCR | 28 | 0.55 | 5.85 × 10–86 | 1.28 × 10–84 |
SLCO4C1 | 1 | 0.54 | 1.90 × 10–83 | 3.93 × 10–82 |
CLDN18 | 1 | 0.53 | 9.85 × 10–82 | 1.91 × 10–80 |
MGST1 | 2 | 0.52 | 4.12 × 10–77 | 6.81 × 10–76 |
CD55 | 3 | 0.51 | 6.88 × 10–72 | 1.00 × 10–70 |
DAPK2 | 1 | 0.47 | 6.68 × 10–61 | 7.62 × 10–60 |
SLC1A1 | 8 | 0.47 | 2.64 × 10–60 | 2.99 × 10–59 |
PDE4D | 44 | 0.45 | 6.43 × 10–55 | 6.02 × 10–54 |
CA2 | 75 | 0.45 | 1.25 × 10–54 | 1.15 × 10–53 |
ADRB2 | 164 | 0.45 | 6.33 × 10–54 | 5.69 × 10–53 |
FGFR2 | 55 | 0.45 | 1.35 × 10–53 | 1.21 × 10–52 |
MET | 118 | 0.44 | 1.11 × 10–52 | 9.48 × 10–52 |
DAPK1 | 3 | 0.44 | 3.86 × 10–51 | 3.05 × 10–50 |
FMO5 | 1 | 0.43 | 5.27 × 10–48 | 3.73 × 10–47 |
SLC22A3 | 4 | 0.40 | 1.95 × 10–41 | 1.08 × 10–40 |
ABCC4 | 30 | 0.40 | 3.30 × 10–41 | 1.80 × 10–40 |
NR3C2 | 29 | 0.38 | 4.28 × 10–38 | 2.16 × 10–37 |
CYP51A1 | 5 | 0.38 | 1.51 × 10–37 | 7.44 × 10–37 |
PDE8A | 4 | 0.37 | 6.24 × 10–35 | 2.77 × 10–34 |
C5 | 10 | 0.36 | 4.38 × 10–33 | 1.81 × 10–32 |
MME | 15 | 0.36 | 5.65 × 10–33 | 2.32 × 10–32 |
CYP4B1 | 2 | 0.34 | 1.08 × 10–29 | 4.00 × 10–29 |
PRKCI | 12 | 0.33 | 2.57 × 10–28 | 9.10 × 10–28 |
PRKCE | 16 | 0.33 | 3.55 × 10–28 | 1.24 × 10–27 |
CAMK2D | 17 | 0.33 | 5.03 × 10–28 | 1.74 × 10–27 |
MAPK8 | 48 | 0.30 | 5.53 × 10–24 | 1.67 × 10–23 |
GRIA1 | 33 | 0.30 | 8.11 × 10–24 | 2.42 × 10–23 |
