Figure 1 | Scientific Reports

Figure 1

From: Cisplatin induced neurotoxicity is mediated by Sarm1 and calpain activation

Figure 1

Cisplatin caused a dose dependent toxicity on rat immortalized DRG neuronal cell line (A) and primary rat DRG neurons (B) as assessed by ATP measurements. Exposure of primary rat DRG neurons also caused a dose-dependent degeneration of neurites (C,D). Panel C shows degeneration and blebbing in representative images of fixed and stained DRG neurons. (n = 3/condition, one-way ANOVA, *p < 0.05, ***p < 0.0005, ****p < 0.0001, error bars denote SEM).

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