Table 2 Significant VIP scores from PLS-DA for all group comparisons by electrospray ionization (ESI) mode and x-variate component.

From: Serum metabolites as biomarkers in systemic sclerosis-associated interstitial lung disease

Metabolite

VIP scores

ESI mode

Groups

Component 1

Component 2

l-Tyrosine

2.05

 

Positive

Healthy vs. all SSc

l-Tryptophan

2.23

2.10

l-Tryptophan

2.76

2.48

Negative

l-Threonine

2.13

 

Positive

ILD vs. non-ILD SSc

3-Aminoisobutyric acid

2.06

 

Adenosine monophosphate

2.48

2.03

Xanthosine

 

2.11

Negative

l-Isoleucine

2.14

 

Positive

Stable vs. progressive SSc-ILD

l-Leucine

2.41

2.21

Adenosine monophosphate

2.01

 

Xanthosine

2.75

2.09

Negative

  1. Significance is defined by VIP values ≥ 2 meaning that these metabolites were essential for the discrimination of different groups of patients in PLS-DA14,21.
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