Figure 3
From: Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-19
Gene Set Enrichment Analysis of MAIC rankings. (A) Violin plots of MAIC score distributions of top enriched pathways significant with both FGSEA and Enrichr algorithms, from the KEGG 2019 (Human) and WikiPathways 2019 (Human) databases. Highly similar pathways and irrelevant specific disease terms are not shown. n: number of gene set members included in the overall MAIC output; NES: normalised enrichment score from FGSEA. (B): Information contribution by methodology for selected enriched KEGG terms. Relative contributions of different information sources vary between functional annotations, but no single methodology predominates to drive enrichment.
