Figure 2 | Scientific Reports

Figure 2

From: High affinity nanobodies block SARS-CoV-2 spike receptor binding domain interaction with human angiotensin converting enzyme

Figure 2

Protein sequences for novel nanobodies that bind to the SARS-CoV-2 spike protein receptor binding domain. Single letter amino acid codes. Clustal Omega algorithm used for alignment. Blue highlights indicate sequence diversity with NIH-CoVnb-112, highlighted in gray, set as the reference sequence for comparison. For comparison, seven previously reported nanobody sequences have clearly distinct sequences: Ty123, VHH7224, H11-D419, MR320, Sb#1421, Sb2322, and W25UACh25 and possess shorter CDR3 domains (represented in NIH-CoVnb-112 by amino acids 99–120).

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