Figure 2 | Scientific Reports

Figure 2

From: DEAD-box RNA helicase protein DDX21 as a prognosis marker for early stage colorectal cancer with microsatellite instability

Figure 2

Representative DDX21 protein detection by immunohistochemistry of TMA cores. (a-c) Benign colonic mucosa with negative or weak cytoplasmic or weak nucleolar staining for DDX21 in enterocytes. (d,e) Representative early stage colorectal cancer with negative staining for DDX21. (f,g) Representative early stage colorectal cancer with strongly positive nuclear DDX21 staining in cancer cells. Note the absence of staining in stromal cells of the lamina propria. (h,i) Representative late stage colorectal cancer with negative staining for DDX21. (j,k) Representative late stage colorectal cancer with strongly positive nuclear DDX21 staining in cancer cells. Note the absence of staining in stromal cells of the lamina propria. Original magnifications: ×20 (a,d,f,h,j) and ×200 (b,c,e,g,i,k).

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