Table 2 Pathological findings in subgroups by glomerular nodular lesions.
Pathological findings of scores | Controls | Diabetes mellitus | p value | Nephrosclerosis | p value | Transplanted allograft | p value | Total | p value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N = 5 | N = 5 | N = 3 | N = 3 | N = 3 | N = 6 | N = 5 | N = 14 | N = 16 | |||||
( −)* | ( +)* | ( −)* | ( +)* | ( −)* | ( +)* | ( −)* | ( +)* | ( −)* | |||||
Glomerular lesions | |||||||||||||
Diffuse lesion (mesangial expansion) | 0.00 | 3.00 | 1.33 | 0.42 | 1.00 | 1.33 | 0.01 | 1.83 | 0.80 | 0.07 | 1.94 | 0.87 | < 0.01 |
Nodular lesion (nodular sclerosis) | 0.00 | 1.00 | 0.00 | < 0.01 | 1.00 | 0.00 | < 0.01 | 1.00 | 0.00 | < 0.01 | 1.00 | 0.00 | < 0.01 |
Subendothelial space widening (double contour of the basement membrane) | 0.00 | 2.60 | 1.67 | 0.40 | 0.67 | 2.00 | 0.49 | 1.83 | 0.20 | 0.04 | 1.7 | 0.97 | < 0.01 |
Exudative lesion | 0.00 | 1.00 | 0.67 | 0.42 | 0.33 | 0.67 | 0.52 | 0.67 | 0.20 | 0.15 | 0.67 | 0.38 | < 0.01 |
Mesangiolysis microaneurysm | 0.00 | 0.80 | 0.33 | 0.24 | 0.33 | 0.00 | 0.42 | 0.33 | 0.00 | 0.18 | 0.49 | 0.08 | 0.01 |
Peri-hilar neovascularization (polar vasculosis) | 0.20 | 1.00 | 0.67 | 0.42 | 0.67 | 1.00 | 0.42 | 0.67 | 0.20 | 0.15 | 0.78 | 0.52 | < 0.01 |
Global glomerulosclerosis Collapsing glomerulopathy Ischemic nephropathy | 1.34 | 43.96 | 24.80 | 0.08 | 10.03 | 0.00 | 0.20 | 26.28 | 3.16 | 0.08 | 26.76 | 7.33 | < 0.01 |
Segmental glomerulosclerosis | 0.00 | 4.98 | 5.47 | 0.86 | 29.57 | 6.67 | 0.20 | 9.20 | 0.76 | 0.11 | 14.58 | 3.22 | 0.04 |
Glomerulomegaly | 0.00 | 1.00 | 0.00 | 0.30 | 0.33 | 0.33 | 1.00 | 0.50 | 0.00 | 0.07 | 0.61 | 0.08 | < 0.01 |
Interstitial lesions | |||||||||||||
Interstitial fibrosis and tubular atrophy (IFTA) | 0.80 | 2.60 | 2.00 | 0.88 | 1.67 | 0.67 | 0.67 | 2.50 | 1.20 | 0.03 | 2.26 | 1.17 | < 0.01 |
Interstitial inflammation | 1.00 | 2.60 | 2.67 | 0.42 | 1.67 | 0.67 | 0.67 | 2.50 | 1.20 | 0.03 | 2.26 | 1.38 | < 0.01 |
Arteriolar hyalinosis | 1.40 | 3.00 | 3.00 | 0.42 | 3.00 | 3.00 | 0.42 | 2.67 | 2.20 | 0.18 | 2.89 | 0.08 | 0.014 |
Vascular lesions | |||||||||||||
Intimal thickening | 1.40 | 2.00 | 1.67 | 0.26 | 2.00 | 1.67 | 0.59 | 2.00 | 1.60 | 0.38 | 2.00 | 1.58 | 0.09 |
Col6-positive rate | 2.20 | 22.81 | 5.10 | 0.03 | 16.84 | 18.81 | 0.29 | 26.95 | 13.28 | 0.03 | 22.20 | 9.85 | < 0.01 |
γ-H2AX-positive rate | 1.94 | 2.87 | 0.46 | 0.16 | 1.40 | 1.01 | 0.71 | 3.22 | 0.80 | 0.22 | 2.50 | 1.05 | 0.11 |
