Table 1 Antibiotic susceptibility profiles of RT106 clinical isolates (this study).

From: Phylogenomic analysis of Clostridioides difficile ribotype 106 strains reveals novel genetic islands and emergent phenotypes

Strain	Minimum inhibitory concentration (MIC)
	Teicoplanin	Cefotaxime	Clindamycin	Erythromycin	Levofloxacin	Moxifloxacin	Tetracycline	Vancomycin	Metronidazole
	0.016–256 mcg/mL	0.002–32 mcg/mL	0.016–256 mcg/mL	0.016–256 mcg/mL	0.002–32 mcg/mL	0.002–32 mcg/mL	0.016–256 mcg/mL	0.016–256 mcg/mL	0.016–256 mcg/mL
GV371	0.125	> 32^a	4^a	> 256^b	4	3	0.50	0.75	0.50
GV423	0.125	> 32^a	6^a	> 256^b	4	3	0.50	1.00	0.50
GV432	0.125	> 32^a	4^a	> 256^b	4	2	0.09	1.00	0.38
GV597	0.094	> 32^a	4^a	2	12^b	4^a	0.38	0.75	0.38
GV453	0.125	> 32^a	4^a	1.50	4	4^a	0.50	1.00	0.50
GV587	0.125	> 32^a	6^a	1	4	4^a	0.50	0.75	0.38
GV642	0.125	> 32^a	4^a	1.50	4	6^a	0.38	0.75	0.50
GV364	0.125	> 32^a	4^a	1	6	2	0.50	1.00	0.50
GV375	0.125	> 32^a	4^a	1	6	2	0.38	0.50	0.75
GV377	0.125	> 32^a	4^a	2	4	3	0.38	0.75	0.75
GV415	0.125	> 32^a	4^a	1	6	3	0.50	1.00	0.50
GV421	0.125	> 32^a	4^a	1	4	2	0.38	0.75	0.75
GV425	0.125	> 32^a	6^a	0.75	4	3	0.06	0.75	0.19
GV426	0.094	> 32^a	4^a	1.50	6	3	0.50	0.75	0.50
GV524	0.125	> 32^a	4^a	0.75	4	3	0.50	0.75	0.38
GV576	0.125	> 32^a	4^a	1	4	3	0.38	0.75	0.50
GV589	0.094	> 32^a	4^a	1	4	2	0.38	0.75	0.50
GV753	0.125	> 32^a	6^a	1	4	3	0.38	0.75	0.50
GV599	0.094	> 32^a	3	1	4	3	0.38	0.50	0.38
GV457	0.094	> 32^a	3	1	4	3	0.13	0.75	0.38
GV515	0.125	> 32^a	3	1	4	2	0.38	1.00	0.50
630	0.064	> 32^a	> 256^b	> 256^b	4	3	64^b	1.50	0.25
VPI	0.032	> 32^a	4^a	1	3	1	0.38	1.00	0.25
T-7	0.064	> 32^a	3	1	4	3	0.50	1.00	0.50
BI-1	0.064	> 32^a	2	1	4	2	0.38	1.50	0.25
CLSI Breakpoints (mcg/mL)	NA	≥ 64 (Resistant)	≥ 8 (Resistant)	NA	NA	≥ 8 (Resistant)	≥ 16 (Resistant)	NA	≥ 32 (Resistant)
	NA	32 (Intermediate Resistance)	4 (Intermediate Resistance)	NA	NA	4 (Intermediate Resistance)	8 (Intermediate Resistance)	NA	16 (Intermediate Resistance)
	NA	≤ 16 (Susceptible)	≤ 2 (Susceptible)	NA	NA	≤ 2 (Susceptible)	≤ 4 (Susceptible)	NA	≤ 8 (Susceptible)
EUCAST Breakpoints (mcg/mL)	NA	NA	NA	NA	NA	NA	NA	≥ 2 (Resistant)	≥ 2 (Resistant)
EUCAST Breakpoints (mcg/mL)	NA	NA		NA	NA	NA	NA	≤ 2(Susceptible)	≤ 2(Susceptible)

Numbers in bold font represent high MIC values.
^aDenotes that strain is moderately resistant to specific antibiotics.
^bDenotes that strain is highly resistant to specific antibiotics.

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Table 1 Antibiotic susceptibility profiles of RT106 clinical isolates (this study).

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