Figure 2

Bivariate correlations of Hsp90 with systemic inflammation, lung function tests, and skin involvement. In all SSc patients, plasma Hsp90 positively correlated with C-reactive protein (CRP) (a), and negatively correlated with lung function parameters, such as forced vital capacity (FVC) (b), forced expiratory volume in one second (FEV1) (c), diffusing lung capacity for carbon monoxide (DLCO) (d), and oxygen saturation assessed by pulse oximetry (SpO2) (e). In patients with diffuse cutaneous (dc)SSc, plasma Hsp90 positively correlated with the extent and severity of skin involvement (black dots), whereas in limited cutaneous (lc)SSc, no significant correlation was found (grey dots) (f).