Table 3 Association of OCLN, CLDN3, CLDN, DSG3 and TSLP expression with clinical parameters of AR patients (n = 30).

From: Reduced occludin and claudin-7 expression is associated with urban locations and exposure to second-hand smoke in allergic rhinitis patients

 

n (%)

OCLN expression

CLDN3 expression

CLDN7 expression

DSG3 expression

TSLP expression

 < Median

 ≥ Median

p-value

 < Median

 ≥ Median

p-value

 < Median

 ≥ Median

p-value

 < Median

 ≥ Median

p-value

 < Median

 ≥ Median

p-value

Family History of Allergic Diseases

Yes

25 (83.3)

13 (43.3)

12 (40.0)

0.336 (F)

13 (43.3)

12 (40.0)

1.000 (F)

12 (40.0)

13 (43.3)

0.355 (F)

11 (36.7)

14 (46.7)

0.642 (F)

10 (33.3)

15 (50.0)

0.157 (F)

No

5 (16.7)

1 (3.3)

4 (13.3)

2 (6.7)

3 (10.0)

1(3.3)

4 (13.3)

3 (10.0)

2 (6.7)

4 (13.3)

1 (3.3)

Classification of AR

Persistent

21 (70.0)

9 (30.0)

12 (40.0)

0.694 (F)

12 (40.0)

9 (30.0)

0.427 (F)

8 (26.7)

13 (43.3)

0.443 (F)

10 (33.3)

11 (36.7)

1.000 (F)

11 (36.7)

10 (33.3)

1.000 (F)

Intermittent

9 (30.0)

5 (16.7)

4 (13.3)

3 (10.0)

6 (20.0)

5 (16.7)

4 (13.3)

4 (13.3)

5 (16.7)

5 (16.7)

4 (13.3)

Conjunctivitis

Yes

22 (73.3)

9 (30.0)

13 (43.3)

0.417 (F)

12 (40.0)

10 (33.3)

0.682 (F)

8 (26.7)

14 (46.7)

0.242 (F)

10 (33.3)

12 (40.0)

1.000 (F)

10 (33.3)

12 (40.0)

1.000 (F)

No

8 (26.7)

5 (16.7)

3 (10.0)

3 (10.0)

5 (16.7)

5 (16.7)

3 (10.0)

4 (13.3)

4 (13.3)

4 (13.3)

4 (13.3)

Pharyngitis

Yes

16 (53.3)

4 (13.3)

12 (40.0)

0.011

8 (26.7)

7 (23.3)

0.715

7 (23.3)

8 (26.7)

0.712

8 (26.7)

8 (26.7)

0.696

7 (23.3)

9 (30.0)

0.732

No

14 (46.7)

10 (33.3)

4 (13.3)

7 (23.3)

8 (26.7)

6 (20.0)

9 (30.0)

6 (20.0)

8 (26.7)

7 (23.3)

7 (23.3)

Asthma

Yes

11 (36.7)

4 (13.3)

7 (23.3)

0.389

6 (20.0)

5 (16.7)

0.704

4 (13.3)

7 (23.3)

0.708 (F)

5 (16.7)

6 (20.0)

0.920

3 (10.0)

8 (26.7)

0.105

No

19 (63.3)

10 (33.3)

9 (30.0)

9 (30.0)

10 (33.3)

9 (30.0)

10 (33.3)

 

9 (30.0)

10 (33.3)

11 (36.7)

8 (26.7)

Sinusitis

Yes

28 (93.3)

12 (40.0)

16 (53.3)

0.209 (F)

14 (46.7)

14 (46.7)

1.000 (F)

11 (36.7)

17 (56.7)

0.179 (F)

14 (46.7)

14 (46.7)

0.485 (F)

13 (43.3)

15 (50.0)

1.000 (F)

No

2 (6.7)

2 (6.7)

0 (0.0)

1 (3.3)

1 (3.3)

2 (6.7)

0 (0.0)

0 (0.0)

2 (6.7)

1 (3.3)

1 (3.3)

Otitis Media

Yes

5 (16.7)

2 (6.7)

3 (10.0)

1.000 (F)

1 (3.3)

4 (13.3)

0.330 (F)

4 (13.3)

1 (3.3)

0.128 (F)

2 (6.7)

3 (10.0)

1.000 (F)

1 (3.3)

4 (13.3)

0.336 (F)

No

25 (83.3)

12 (40.0)

13 (43.3)

14 (46.7)

11 (36.7)

8 (26.7)

17 (56.7)

12 (40.0)

13 (43.3)

13 (43.3)

12 (40.0)

Sensitivity to HDM allergen

D. farina

Yes

24 (80.0)

11 (36.7)

13 (43.3)

1.000 (F)

13 (43.3)

11 (36.7)

0.651 (F)

11 (36.7)

13 (43.3)

0.672 (F)

11 (36.7)

13 (43.3)

1.000 (F)

11 (36.7)

13 (43.3)

1.000 (F)

No

6 (20.0)

3 (10.0)

3 (10.0)

2 (6.7)

4 (13.3)

2 (6.7)

4 (13.3)

3 (10.0)

3 (10.0)

3 (10.0)

3 (10.0)

D. pteronysinnus

Yes

19 (63.3)

9 (30.0)

10 (33.3)

0.920

9 (30.0)

10 (33.3)

0.704

11 (36.7)

8 (26.7)

0.057 (F)

6 (20.0)

13 (43.3)

0.030

9 (30.0)

10 (33.3)

0.920

No

11 (36.7)

5 (16.7)

6 (20.0)

6 (20.0)

5 (16.7)

2 (6.7)

9 (30.0)

8 (26.7)

3 (10.0)

5 (16.7)

6 (20.0)

B. tropicalis

Yes

21 (70.0)

10 (33.3)

11 (36.7)

1.000 (F)

12 (40.0)

9 (30.0)

0.427 (F)

7 (23.3)

14 (46.7)

0.123 (F)

11 (36.7)

10 (33.3)

0.440 (F)

9 (30.0)

12 (40.0)

0.694

No

9 (30.0)

4 (13.3)

5 (16.7)

3 (10.0)

6 (20.0)

6 (20.0)

3 (10.0)

3 (10.0)

6 (20.0)

5 (16.7)

4 (13.3)

  1. p < 0.05 shown in bold. Abbreviation: AR, allergic rhinitis; OCLN, occludin; CLDN3, claudin-3; CLDN7, claudin-7; DSG3, desmoglein 3; TSLP, thymic stromal lymphopoietin; HDM, house dust mite.