Figure 7
From: Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist
Weaker allosteric signalling by SS-RJW100 in MDS. (a) Model of the LRH-1 LBD with the AF-B and AFS highlighted in cyan. (b) RMSFs for each complex over the course of the 1 microsecond simulation. The diagram at the top of the graph indicates the position in the protein. Grey box indicates the AF-B. (c) Histogram of the top 1000 suboptimal paths between AF-B and the AFS for the three complexes.
