Figure 4
From: Central dopamine D2 receptors regulate plasma glucose levels in mice through autonomic nerves
Effects of the dopamine D2 receptor agonist and antagonist on secretion of hormones and hepatic glucose production. (a–d) Effects of quinpirole (10 μg, i.c.v.; a, c) and l-sulpiride (10 μg, i.c.v.; b, d) on plasma glucagon (a, b) and insulin (c, d) levels. Blood samples were collected 10 min after drug injections. (e, f) Effect of quinpirole (10 μg, i.c.v.; e) and l-sulpiride (10 μg, i.c.v.; f) on hepatic glycogen levels. Liver samples were collected 30 min after drug injections. (g–j) Effect of quinpirole (10 μg, i.c.v.; g, i) and l-sulpiride (10 μg, i.c.v.; h, j) on hepatic mRNA levels of glucose-6-phosphatase (G6Pase; g, h) and phosphoenolpyruvate carboxykinase (PEPCK; i, j). Liver samples were collected 30 min after drug injections. Each point represents the mean ± S.E.M. of 6–14 mice. *P < 0.05, **P < 0.01 vs. vehicle group.
