Table 2 Cytotoxicity of DTX, DOX and Erlotinib in 2D monolayers and 3D spheroids of NSCLC-PDX, MDAMB-231 WT, and HCC-827 cells.

From: Polysaccharide hydrogel based 3D printed tumor models for chemotherapeutic drug screening

Cell lines

DTX IC50 (µM)

DOX IC50 (µM)

Erlotinib IC50 (µM)

2D culture

3D culture

2D culture

3D culture

2D culture

3D culture

NSCLC-PDX

1.63 ± 0.23

16.20 ± 1.67

  

52.12 ± 3.22

152.5 ± 5.67

MDA-MB-231 WT

1.82 ± 0.32

15.10 ± 2.36

1.58 ± 0.32

77.35 ± 2.36

52.50 ± 5.26

131.53 ± 2.36

HCC827

6.83 ± 0.89

64.50 ± 4.56

10.73 ± 1.65

85.35 ± 6.56

48.53 ± 3.65

138.79 ± 4.56

  1. DOX was not used for NSCLC PDX cells due to its lack of effectiveness against lung cancer. The experimental results were expressed as mean ± standard deviation.
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