Figure 5 | Scientific Reports

Figure 5

From: T-cell receptor repertoire of cytomegalovirus-specific cytotoxic T-cells after allogeneic stem cell transplantation

Figure 5

Clonal dynamics of CMV-CTLs. (a) T-cell receptor-beta repertoire of cytomegalovirus-specific cytotoxic T-cells (CMV-CTLs) and its changes over time. Two cases with remarkable changes in diversity are highlighted in red. (b,c) Frequency of each TRBV (b) and TRBJ (c). (d) A 3D graphical plot of T-cell repertoire of CMV-CTLs at the time of CMV reactivation (above) and 3 weeks after (below) for Case 15. (e) Frequency and time course for each CMV-CTL clonotype in Case 15. Clonotypes that accounted for ≥ 1% were represented. (f) 3D graphical plot of T-cell repertoire of CMV-CTLs at the time of CMV reactivation (above) and 2 weeks after (below) for Case 8. (g) Frequency and time course for each CMV-CTL clonotype in Case 8. Clonotypes that accounted for ≥ 1% were represented. (h) A 3D graphical representation of the TCR repertoire of CMV-CTLs 2–4 weeks after CMV reactivation.

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