Table 3 The SNPs significant association with three adverse reactions in AML group.
SNP | Gene | Chromosome position (bp) | Source | Outcome /status | Recipient Genotype frequency (%) | Test | p-value | OR (95% CI) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
Donor group | |||||||||||
rs11244 | HLA-DOB | Chr 6: 32812947 | rs2071479 | CMV | A/A | A/G | G/G | ||||
3′UTR | Yes | 21 | 41 | D | 0.019 | 0.379 (0.167–0.858) | |||||
No | 2 | 21 | 17 | ||||||||
rs209131 | TRIM27 | Chr 6: 28899978 | rs209130 | CMV | A/A | A/G | G/G | ||||
~ 3 k downstream | Yes | 16 | 28 | 19 | R | 0.034 | 0.322 (0.109–0.946) | ||||
No | 10 | 26 | 5 | ||||||||
rs2518028 | HCP5 | Chr6: 31468270 | rs2244546 | Survival | C/C | C/T | T/T | ||||
~ 2.5 k downstream | Yes | 38 | 15 | 1 | R | 0.026 | 8.833 (1.045–74.633) | ||||
No | 29 | 13 | 7 | ||||||||
rs17220087 | HLA-DOB | Chr 6: 32813299 | rs2071479 | Survival | A/A | A/C | C/C | ||||
3′UTR | Yes | 3 | 50 | D/A | 0.047 | 3.750 (0.952–14.775) | |||||
No | 9 | 40 | |||||||||
rs1536215 | TRIM27 | Chr 6: 28900138 | rs209130 | GVHD3-4 | C/C | C/G | G/G | ||||
~ 3 k downstream | Yes | 9 | 12 | 1 | D | 0.021 | 3.056 (1.159–8.056) | ||||
No | 55 | 23 | 3 | ||||||||
Recipient group | |||||||||||
rs209132 | TRIM27 | Chr 6: 28899705 | rs209130 | CMV | A/A | A/G | G/G | ||||
~ 3 k downstream | Yes | 2 | 23 | 37 | D | 0.022 | 0.390 (0.173–0.879) | ||||
No | 5 | 21 | 15 | ||||||||
rs209131 | TRIM27 | Chr 6: 28899978 | rs209130 | CMV | A/A | A/G | G/G | ||||
~ 3 k downstream | Yes | 7 | 34 | 21 | R | 0.042 | 0.347 (0.122–0.989) | ||||
No | 11 | 23 | 7 | ||||||||
rs2070120 | HLA-DOB | Chr 6: 32813137 | rs2071479 | CMV | A/A | A/G | G/G | ||||
3′UTR | Yes | 11 | 52 | D/A | 0.026 | 0.118 (0.015–0.954) | |||||
No | 1 | 40 | |||||||||
rs17213693 | HLA-DOB | Chr 6: 32813344 | rs2071479 | CMV | C/C | C/G | G/G | ||||
Intron | Yes | 1 | 11 | 51 | D | 0.043 | 4.471 (0.944–21.163) | ||||
No | 2 | 38 | |||||||||
rs79327197 | HLA-DOA | Chr 6: 33010635 | rs9276982 | Survival | A/A | A/G | G/G | ||||
Promoter | Yes | 51 | 4 | D/A | 0.008 | 0.217 (0.065–0.720) | |||||
NO | 36 | 13 | |||||||||
SNP | Gene | Chromosome position (bp) | Source | Outcome /status | Genotypes between the Donor-Recipient Pairs | Test | p-value | OR (95% CI) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
Donor-recipient pairs | |||||||||||
rs209131 | TRIM27 | Chr 6: 28899978 | rs209130 | CMV | Matched | Unmatched | |||||
~ 3 k downstream | Yes | 34 | 28 | Chi-square | 0.016 | 0.342 (0.140–0.834) | |||||
No | 32 | 9 | |||||||||
rs17213693 | HLA-DOB | Chr 6: 32813344 | rs2071479 | CMV | Matched | Unmatched | |||||
Intron | Yes | 50 | 12 | Chi-square | 0.044 | 0.225 (0.048–1.068) | |||||
No | 37 | 2 | |||||||||
rs107822 | RING1 | Chr 6: 33207798 | rs107822 | Survival | Matched | Unmatched | |||||
Promoter | Yes | 25 | 28 | Chi-square | 0.016 | 0.368 (0.161–0.838) | |||||
No | 34 | 14 | |||||||||
rs3130048 | BAG6 | Chr 6: 31645962 | rs2242656 | GVHD3-4 | Matched | Unmatched | |||||
Intron | Yes | 15 | 7 | Fisher’s exact test | 0.048 | 0.302 (0.099–0.920) | |||||
No | 71 | 10 | |||||||||
