Figure 2 | Scientific Reports

Figure 2

From: Continuous monitoring of neutrophils to lymphocytes ratio for estimating the onset, severity, and subsequent prognosis of immune related adverse events

Figure 2

NLR trends in patients with interstitial pneumonitis. (a) Plotting the NLR trends during 100 days before development of ICI-related interstitial pneumonitis. The gray line indicates the individual patients (n = 26), and the red line shows the mean ± SEM. At 0 day is the initial detection of pneumonitis. (b) The NLR was significantly elevated not only at incidences of pneumonitis, but also 4 and 2 weeks in advance. (c) NLR elevation at pneumonitis development was compared among the severity of the irAEs. (d) ROC curve analysis of the sensitivity and specificity of NLR elevation from baseline to distinguish between Grade 1 or 2 and Grade 3 or higher pneumonitis (sensitivity 88.9%, specificity 88.2%, cut-off 2.37, p = 0.0004). Statistical analysis included one-way ANOVA with mixed-effects model followed by Holm-Sidak’s post hoc test (b), and one-way ANOVA with Tukey’s post hoc test (c). Data are shown as the mean ± SEM (b, c), *p < 0.05, **p < 0.01, and ***p < 0.005. NLR neutrophil-to-lymphocyte ratio, ICI immune checkpoint inhibitor, irAE immune-related adverse event, ROC receiver operating characteristics.

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