Figure 2 | Scientific Reports

Figure 2

From: Metabolic changes and anti-tumor effects of a ketogenic diet combined with anti-angiogenic therapy in a glioblastoma mouse model

Figure 2

(A) Comparison of β-OHB concentration in the tumor and normal brain in each group. In the ketogenic diet groups (KD and KD + Bev), it is markedly increased (*p < 0.05, **p < 0.01, and Tukey–Kramer test). (B) PCA analysis of the tumor tissue in each of the four groups. (C) VIP score analysis of the tumor tissue. (D) Heat map showing characteristic metabolite changes in the tumor tissue in each group. (E) Comparison of the amino acids levels in the control, KD, Bev, and KD + Bev groups. Note several amino acids increase by the KD, and most of the amino acids decrease in KD + Bev group. In particular, the change in aspartic acid is most significant (*p < 0.05, **p < 0.01, and Tukey–Kramer test).

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