Table 2 Summary of PFO cases.

Product	Company	Origin	Outbreack years	Affected patients in Spain	Other countries affected^a	Cytotoxic tested batches	% Cell mortality^d	Identified impurities	References
MEROCTANE	Meran	Turkey	2013	4	Chile^c	OCT.01.2013	91	Tridecafluorotridecane	¹⁰
								1H,1H,7H-Dodecafluoro-1-heptanol
								1H,1H,9H-Hexadecafluoro-1-nonanol
								Tridecafluorohexane
								1H,1H,11H-Eicosafluoro-1-undecanol
								Perfluorododecanoic acid
								Pentadecafluoro octanoic acid, methyl ester
								Pentadecafluorooctanoic acid, isopropyl ester
ALA OCTA	Alamedics	Germany	2014–2015	117	France	171214	99	Leachables (dimethylbenzene, ethylbenzene, p-xylene)	^{2,3,4,5,8,9,10}
					Italy	061014	99	Perfluorooctanoic acid
					Switzerland^b	070714	47	1H,1H,7H-Dodecafluoro-1-heptanol
					Sweden	050514	50	Underfluorinated impurities
					Saudi Arabia	200114	44	Perfluorinated alkenes
						180214	41	Perfluororurane
						150414	66	1H-Perfluoroalkane analog
						080714	47	1H-Perfluorooctane
								Perfluorooctanoic acid methyl ester
BIO OCTANE PLUS	Biotech Opthalmology PVT	India	2016	4		1605148	99	Tri-n-butyltinbromide	^2,5,10

^aCases recognized by clinicians in different meetings and in some publications, but without access to official data from the National Health Agencies.
^bAt least 48 cases recently published (see references).
^cAlthough they could not be included in this publication due to lack of data, there is evidence of at least 24 cases in Chile.
^dDetermined by the direct method developed by the IOBA (see references).

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