Figure 2
From: Clinically-identified C-terminal mutations in fibulin-3 are prone to misfolding and destabilization
Secretion of F3 variants. (A) Western blot of secreted and intracellular levels of F3 variants in HEK293A cells. Asterisk indicates truncated intracellular Q226H band. (B) Quantification of secreted, intracellular, and (C) secretion propensities of F3 variants shown in (A), n ≥ 6, mean ± SEM (*p < 0.05, **p < 0.01, ***p < 0.001, one sample t test vs. a hypothetical value of 1 [i.e., unchanged]).
