Table 2 TAC concentration/weight-adjusted dose ratio (C/D/Kg) in the first 15 days from transplantation stratified by donor CYP3A5 genotype, recipient age and GRWR. Asterisks (*) indicate statistically significant differences between the marked group and the others.
Post-transplant days | TAC C/D/Kg (median and interquartile range) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 8 | Day 9 | Day 10 | Day 11 | Day 12 | Day 13 | Day 14 | Day 15 | ||
Donor CYP3A5 gen | Quartiles | |||||||||||||||
CYP3A5 *1/*3 | 1 | 32.5 | 27.9 | 33.6 | 28.0 | 27.1 | 23.3 | 24.5 | 21.5 | 20.4 | 17.2 | 17.0 | 21.0 | 23.0 | 20.6 | 19.6 |
2 | 62.4 | 51.5 | 47.5 | 42.4 | 41.5 | 57.3 | 40.7 | 39.7 | 27.5 | 28.4 | 34.0 | 34.1 | 34.2 | 30.4 | 32.7 | |
3 | 93.1 | 74.0 | 63.4 | 73.5 | 80.5 | 85.5 | 59.8 | 68.0 | 44.7 | 45.1 | 50.5 | 65.3 | 113.3 | 65.2 | 136.3 | |
CYP3A5*3/*3 | 1 | 71.5 | 53.1 | 61.4 | 46.0 | 45.7 | 38.1 | 35.3 | 40.3 | 33.7 | 29.7 | 28.2 | 29.6 | 37.7 | 30.9 | 35.1 |
2 | 147.3* | 85.8* | 122.2* | 111.7* | 93.0* | 74.0* | 67.2* | 70.2* | 60.8* | 57.6* | 54.6 | 63.0 | 60.1 | 54.7 | 50.4 | |
3 | 194.3 | 144.4 | 199.3 | 190.5 | 164.4 | 156.2 | 121.9 | 103.0 | 123.8 | 94.2 | 84.3 | 103.7 | 92.9 | 81.8 | 84.0 | |
p values | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | 0.050 | 0.022 | 0.023 | < 0.001 | 0.025 | 0.071 | 0.122 | 0.124 | 0.073 | 0.272 | |
Recipientage | Quartiles | |||||||||||||||
< 2 years | 1 | 55.7 | 30.8 | 33.6 | 35.3 | 31.2 | 22.1 | 24.5 | 24.0 | 20.9 | 18.1 | 20.5 | 20.6 | 27.8 | 24.2 | 18.4 |
2 | 94.8 | 62.8 | 58.7 | 49.0 | 45.1 | 57.0 | 39.0 | 43.2 | 34.4 | 35.6 | 30.0 | 39.4 | 46.1 | 32.8 | 36.9 | |
3 | 172.36 | 94.3 | 187.1 | 165.2 | 96.0 | 93.5 | 73.8 | 93.3 | 70.5 | 86.2 | 72.6 | 120.5 | 93.5 | 79.8 | 78.4 | |
2–8 years | 1 | 39.60 | 29.7 | 22.3 | 29.6 | 40.8 | 33.6 | 25.4 | 38.1 | 24.0 | 22.6 | 26.8 | 23.5 | 27.5 | 27.8 | 31.9 |
2 | 70.0 | 56.3 | 66.9 | 57.0 | 70.4 | 60.2 | 57.2 | 62.7 | 41.9 | 41.9 | 44.7 | 46.3 | 43.3 | 47.3 | 53.6 | |
3 | 102.86 | 85.6 | 120.2 | 127.0 | 128.6 | 109.4 | 92.4 | 96.8 | 78.5 | 76.2 | 81.2 | 76.8 | 89.5 | 63.6 | 77.8 | |
≥ 8 years | 1 | 117.0 | 83.0 | 91.3 | 63.9 | 64.3 | 49.5 | 40.2 | 45.2 | 34.0 | 40.5 | 39.7 | 38.5 | 40.6 | 48.0 | 41.5 |
2 | 138.9* | 128.4* | 137.8* | 125.4* | 137.9* | 136.0* | 94.3* | 76.1 | 67.4 | 58.8 | 62.5 | 66.4 | 68.5 | 77.3 | 82.0 | |
3 | 205.0 | 166.2 | 198.1 | 244.4 | 183.8 | 177.0 | 141.9 | 109.4 | 125.1 | 92.5 | 85.3 | 93.0 | 128.5 | 128.0 | 127.4 | |
p values | 0.022 | 0.002 | 0.036 | 0.056 | 0.016 | 0.024 | 0.024 | 0.200 | 0.073 | 0.208 | 0.210 | 0.648 | 0.552 | 0.051 | 0.108 | |
GRWR | Quartiles | |||||||||||||||
Normal (2–3%) | 1 | 63.8 | 52.6 | 47.8 | 45.5 | 40.3 | 37.4 | 36.4 | 39.7 | 30.6 | 35.1 | 45.9 | 36.2 | 28.1 | 35.1 | 32.5 |
2 | 92.7 | 74.1 | 87.1 | 64.8 | 94.6 | 95.7 | 61.3 | 65.8 | 60.8 | 57.0 | 62.5 | 61.3 | 55.0 | 56.0 | 74.3 | |
3° | 168.1 | 138.0 | 196.4 | 187.9 | 157.3 | 156.2 | 123.5 | 81.9 | 117.0 | 83.1 | 79.0 | 79.7 | 96.0 | 97.0 | 85.9 | |
Large (3–5%) | 1° | 65.5 | 55.4 | 61.7 | 41.2 | 37.4 | 44.6 | 26.1 | 30.9 | 23.8 | 17.0 | 21.4 | 26.0 | 37.5 | 27.7 | 17.2 |
2° | 153.1 | 80.9 | 143.9 | 108.4 | 64.7 | 59.5 | 41.3 | 43.3 | 36.8 | 33.8 | 37.2 | 46.4 | 67.2 | 58.2 | 55.1 | |
3° | 203.8 | 143.4 | 189.2 | 169.8 | 96.0 | 78.3 | 79.7 | 77.9 | 87.5 | 95.4 | 88.6 | 144.2 | 93.5 | 82.9 | 106.1 | |
Extra-large (> 5%) | 1° | 32.8 | 30.8 | 20.8 | 19.6 | 32.5 | 21.9 | 22.3 | 25.9 | 21.9 | 17.4 | 17.4 | 20.3 | 24.4 | 21.8 | 18.9 |
2° | 56.1 | 53.1 | 38.9* | 37.0* | 45.1* | 30.4* | 25.4* | 43.3* | 28.7* | 32.6 | 25.9 | 27.7 | 39.5 | 29.1 | 36.2 | |
3° | 161.4 | 71.8 | 53.5 | 76.3 | 99.2 | 49.1 | 51.5 | 110.7 | 71.8 | 82.4 | 71.4 | 58.8 | 50.1 | 32.9 | 56.4 | |
p values | 0.348 | 0.142 | 0.015 | 0.013 | 0.002 | < 0.001 | < 0.001 | 0.023 | 0.008 | 0.092 | 0.845 | 0.594 | 0.833 | 0.017 | 0.210 | |
