Table 3 The concentrations of the ADA, cytokines and chemokines in pleural effusions*.

From: Potential diagnostic value of pleural fluid cytokines levels for tuberculous pleural effusion

 

TPE

MPE

p value

EMP

p value

PPE

p value

Non-TPE

p value

IL-27 (pg/ml)

4725 (3993–7598)

838.5 (715.5–967.5)

 ≤ 0.0001

1403 (1163–1720)

 ≤ 0.0001

1409 (1003–1699)

0.002

978 (835.3–1401)

 ≤ 0.0001

IL-6 (pg/ml)

5735 (4935–6302)

1240 (783.3–1955)

 ≤ 0.0001

4114 (3413–5150)

 ≤ 0.0001

2875 (1957–4167)

 ≤ 0.0001

2273 (1121–3832)

 ≤ 0.0001

IL-18 (pg/ml)

2196 (513.4–3035)

568.5 (395–800.3)

0.0008

2409 (1156–4595)

0.2522

2196 (1487–2663)

0.5539

1003 (577.8–2291)

0.1797

CXCL8 (pg/ml)

1038 (344.1–1853)

125 (66.5–599.6)

 ≤ 0.0001

184.5 (114.1–1041)

0.0093

98.02 (50.25–326.5)

 ≤ 0.0001

123 (67.75–485.6)

 ≤ 0.0001

CCL1 (pg/ml)

565 (104.8–2353)

12.21 (6.4–23.35)

 ≤ 0.0001

42.9 (30.18–61.98)

0.0195

126.3 (42.65–392.3)

 ≤ 0.0001

32.2 (12.2–61.98)

 ≤ 0.0001

IP-10 (pg/ml)

2833 (909–4184)

662 (300.7–1524)

 ≤ 0.0001

1503 (1157–3323)

0.3892

823.4 (484.9–2286)

0.0101

944.4 (355.5–1970)

0.0001

ADA (IU/l)

42.73 ± 1.71

14.5 ± 0.6

 ≤ 0.0001

25 ± 1.11

 ≤ 0.0001

21.21 ± 0.32

 ≤ 0.0001

18.9 ± 0.07

 ≤ 0.0001

ADA.IL-27 (103 ng IU/l2)

208.5 (178.2–548.8)

12.2 (9.15–13.53)

 ≤ 0.0001

33.86 (26.46–4.52)

 ≤ 0.0001

30.25 (21.57–35.23)

 ≤ 0.0001

19.23 (13.33–48.96)

 ≤ 0.0001

  1. All values except those for ADA and ADA.IL-27 are presented as the median and 25–75% percentile and comparisons made between TPE and the other groups were performed using the Mann–Whitney U test.
  2. Values for ADA and ADA.IL-27 are shown as mean ± SEM. Comparisons of data between TPE and non-TPE groups were performed using the Student’s t test.
  3. IL interleukin, CXCL C-X-C motif chemokine ligand, CCL C–C motif chemokine ligand, IP-10 interferon gamma-induced protein 10 or CXCL10, ADA adenosine deaminase.
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